| abstract |
The invention discloses a class of naphthylurea-piperazine compounds and a preparation method and application thereof. The compounds can significantly inhibit the activation of cell signal transduction JAKs/STATs signals at low doses, cell proliferation experiments, immunoblotting experiments, cell The results of cycle experiments, protein transmembrane transport experiments, and cell invasion and migration experiments showed that these compounds can specifically inhibit the activation of JAK2 signaling and the expression of downstream target genes such as STAT3, CyclinD1, CyclinB1, and MMP9, and induce cell cycle G1 arrest. These compounds can significantly inhibit the proliferation of various tumor cell lines such as breast cancer, liver cancer, lung cancer, colon cancer, leukemia, lymphoma, multiple myeloma and retinoblastoma, indicating that these compounds have the potential to develop Prospects of targeted anticancer drugs for JAKs/STATs cells to regulate signaling pathway-related targets. |