| abstract |
The invention belongs to the technical field of medicinal chemistry, and discloses a Fascaplysin derivative and a preparation method and application thereof. The chemical structural formula of the Fascaplysin derivative is shown in formula (I), which can induce ferroptosis, induce iron accumulation, induce the increase of reactive oxygen species, inhibit the expression of GPX4, SLC7A11, and FTH1. agent, induces ferroptosis in tumor cells, and is used to treat tumors. |