http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114685498-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e4a4645b55e35a472de063e501ff4f2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 |
| filingDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_444e61e97973b2a6a469d20268a76a1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_345eb745cd4b554cff327185594e44cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96a52596d683f297d45dec94ad6b2b23 |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114685498-A |
| titleOfInvention | A kind of preparation method of varenicline tartrate impurity |
| abstract | The invention proposes a method for preparing a varenicline tartrate impurity. Ammonium formate is used as a hydrogen donor, and a dinitro compound undergoes a reduction reaction under the catalysis of palladium carbon to obtain a diamino compound. Under the catalysis of acid, a cyclization reaction occurs, and the trifluoroacetyl group is removed. After the reaction is completed, the solvent is evaporated, and the concentrate is dissolved in dichloromethane and water. The water phase is extracted twice with dichloromethane, and the organic phases are combined and concentrated to dryness under reduced pressure. . Dissolve the concentrate in ethanol, add concentrated hydrochloric acid dropwise to form a salt, filter and dry to obtain the hydrochloride of impurity II. The present invention provides the preparation method of impurity II for the first time, which can be better applied to the existing preparation process of varenicline tartrate, improve the identification and separation of impurities, and improve product quality. |
| priorityDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.