| abstract |
The invention belongs to the technical field of crystal drug molecules, in particular to the technical field of topicastat crystal forms, in particular to a topicastat maleate dihydrate co-crystal and a preparation method thereof. The molar ratio of lyric acid to water was 1:1:2, using Cu‑Kα radiation, the X-ray diffraction pattern expressed in 2θ was at 8.04±0.2°, 16.28±0.2°, 24.61±0.2°, 24.68±0.2°, There are characteristic peaks at 33.07±0.2° and 33.17±0.2°; the co-crystal of topirastat maleate dihydrate prepared by the present invention has good stability, and has good solubility and stability, which is good for improving topistatt maleate dihydrate. The bioavailability and preparation of pilastat are of great significance. |