http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114685421-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-62 |
| filingDate | 2020-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fac1230ac0e97f6ff36d1eebdd2e83bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_238510f169b25b2ad751eaf4036d9b67 |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114685421-A |
| titleOfInvention | A kind of galantamine intermediate compound |
| abstract | The invention belongs to the field of medicine and chemical industry, in particular to a galantamine intermediate compound. The present invention uses compound II as a raw material to obtain a new intermediate compound III through bromination reaction; the present invention also provides a new method for synthesizing galantamine by using the intermediate, and the new intermediate compound III is ring-closed under the action of an oxidant to obtain compound IV , and then debrominated, methylated, and reduced to obtain galantamine. Compared with the prior art, the method solves the problem of poor regioselectivity in the subsequent oxidative cyclization step. In the next step of the oxidative cyclization reaction, there are no main impurities, so that the reaction yield is higher, the post-processing process is simplified, and the cost, more suitable for industrial production. |
| priorityDate | 2020-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.