| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b92e8e22af79ab374e738cd010c72a2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 |
| filingDate |
2021-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46685cd8789ec850f7f006f18a8d9eb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f2f4725e392afa5a2dde8159c354c16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8db84f4e02a8f50bc824a1ba0a3005d |
| publicationDate |
2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114685317-A |
| titleOfInvention |
A kind of preparation method of medicine for treating epilepsy |
| abstract |
The invention belongs to the field of drug synthesis and discloses a preparation method of a drug for treating epilepsy. The present application obtains the R-enantiomeric compound II of at least 98% enantiomeric purity by O-methylation using dimethyl sulfate in an anhydrous tetrahydrofuran solution of an inorganic base, and then compound II forms an amide with benzylamine, The drug for the treatment of epilepsy is synthesized by deprotection and N-acetylation. The method described in the present application does not use expensive and highly toxic reagents, reduces the amount of methylation reagents, does not generate by-products, and realizes low-toxicity and low-pollution synthesis. |
| priorityDate |
2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |