| abstract |
The present invention provides a kit for promoting drug brain penetration to repair neurons and its application. The kit consists of a brain-targeted small molecule compound delivery system for enhancing brain penetration and a macromolecular polypeptide or macromolecular polypeptide delivery system . The kit provided by the present invention can promote the delivery system of macromolecular polypeptides and brain-targeting macromolecular polypeptides into the brain. The kit of the present invention, when the two are administered sequentially, has a better curative effect than macromolecular polypeptides or brain-targeting alone. Macromolecular polypeptide delivery system. The kit of the invention can be used in the preparation of drugs for treating neurodegenerative diseases by opening the blood-brain barrier, improving drug brain penetration, increasing drug concentration in neuron lesions, reducing neuroinflammation, and promoting neuron regeneration. |