http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114681609-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2022-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f08b96877af5ec78f302d15557d7e533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f36e21f020da09eb1fd45ca2a9f375f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ef3b3a8a7791a280099436bc8a21c01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d33e9dd68056866c951ef4935b743d4e |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114681609-A |
| titleOfInvention | Application of anti-IL-6 antibody composition in preparation of medicament for treating hepatocellular carcinoma |
| abstract | The present invention provides an application of an anti-IL-6 antibody composition in the preparation of a drug for treating hepatocellular carcinoma, the composition comprising an anti-IL-6 antibody and a phosphoinositide-3-kinase-rapamycin target small molecule inhibitor (NVP‑BEZ235) combination. The present invention is based on the discovery that NVP-BEZ235 can cause an increase in the expression level of the pro-inflammatory cytokine IL-6 after administration. It is proved by experiments that the composition group significantly delays the tumor progression and prolongs the survival time of tumor-bearing mice after treatment. Furthermore, the combination of the present invention is expected to prepare a drug that can improve the therapeutic effect of NVP-BEZ235 and can be applied to the treatment of hepatocellular carcinoma. |
| priorityDate | 2022-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.