| abstract |
The invention belongs to the technical field of pharmaceutical preparations. The invention provides an enteric-coated sustained-release preparation of the antiepileptic drug valproamide for taking once a day. The preparation is in the form of a sustained-release matrix tablet core plus an enteric-coated sustained-release tablet. Wherein the core matrix sustained-release material is cellulose derivatives, especially cellulose ethers, such as HPMC, CMC, MC, HPC, and the coating isolation layer contains one or more of gastric-soluble HPMC, HPC, PEG, PVP, and AEA. The enteric layer contains one or more of enteric HPMC, acrylic resin, PAP, CAP, etc. The preparation of the invention is convenient for patients to take and has few side effects. |