http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114671807-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb7529185e0cfc3bbf91d6fdb16e9a9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-02 |
| filingDate | 2020-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eade7af647d0f0135d07cae94de0d2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e730da0b59f1f6d44987304518c514c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7583962ebd2cff010d4a495d9794652d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbcc70d44e888d2194370218b078bd27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f909b55893c0e649657a509a3bbefd56 |
| publicationDate | 2022-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114671807-A |
| titleOfInvention | A kind of preparation method of 1-substituted isoquinoline compounds |
| abstract | The invention discloses a preparation method of 1-substituted isoquinoline compounds. The invention provides a preparation method of 1-substituted isoquinoline compounds, which comprises the following steps: Step 1: in an organic solvent, the isoquinoline compounds are coupled with an organometallic reagent containing an M-C bond reaction to obtain mixture A; wherein, the 1-position of the isoquinoline compound is not substituted; step 2: quenching the mixture A with a quenching reagent to obtain mixture B; step 3: after dehydration In the presence of a hydrogen reagent, the above mixture B is subjected to a dehydrogenation reaction to obtain a 1-substituted isoquinoline compound; the 1-substituted isoquinoline compound is the described organometallic containing M-C bond The C in the reagent is substituted at the 1-position of the isoquinoline compounds. The preparation method of the invention can improve the reaction yield, reduce the reaction cost and reduce the discharge of three wastes. |
| priorityDate | 2020-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 172.