| abstract |
The present invention relates to the application of PDIA6 protein or its active fragment in preparing medicine for treating spinal cord injury and repairing. In the present invention, a large number of studies have confirmed that PDIA6 plays a key role in SCI, and interacts with spastin to regulate neurite outgrowth, proving that the expression level of PDIA6 is up-regulated in the process of SCI, and PDIA6 can physically interact with spastin in vivo and in vitro effect. At the same time, it was also found that the interaction of PDIA6 and spastin can not only promote the growth of neuron neurites, but also promote the repair of damaged neurons. The invention clarifies that PDIA6 is a key target in the process of spinal cord injury and repair, plays a role in regulating neurite growth and branching, and provides practical experimental evidence and scientific basis for clinical treatment of spinal cord injury. |