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filingDate 2022-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b90f2897486b8237ff7923b0b66018a
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publicationDate 2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114632195-A
titleOfInvention A degradable occluder for anticoagulation and promoting myocardial tissue repair and preparation method thereof
abstract The invention discloses a degradable occluder for anticoagulation and promoting myocardial tissue repair and a preparation method thereof, and relates to the technical field of biomedical engineering functional materials. The surface of the degradable occluder is covered with multiple layers of activated treatment solution The albumin and recombinant humanized collagen layers are based on albumin, and the albumin and recombinant humanized collagen layers on the surface participate in the cross-linking reaction. The albumin primer coating prepared by the activated treatment solution and high temperature of the invention has firm interface binding force with the base degradable occluder material, and can effectively adjust the albumin in the coating through simple layered gradient adsorption and assembly. and the content of recombinant humanized collagen, the recombinant humanized collagen used was screened for cell adhesion segments containing GER and GEK that avoided hydroxyproline (O) and had relatively concentrated positive and negative charges. Collagen prepared by fermentation engineering is a substance with both anticoagulant properties and promoting myocardial tissue repair properties.
priorityDate 2022-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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