| abstract |
The present application discloses an immunogen of SARS-CoV-2 virus, a pharmaceutical composition and an application thereof. The immunogen includes a variety of proteins, and the multiple proteins can be assembled to form SARS-CoV-2 virus-like particles. Said multiple proteins include: full-length S protein or S protein RBD domain or PreS protein of SARS-CoV-2 virus, and said S protein or S protein RBD domain or PreS protein can be displayed on said SARS-CoV-2 on the envelope of virus-like particles, thereby giving the SARS-CoV-2 virus-like particles a good immune presentation effect, which can induce the body to produce high titer neutralizing antibodies, stimulate the body to produce an ideal immune response, and achieve effective The purpose of preventing COVID‑19. |