| abstract |
The invention relates to the field of medicine, in particular to the field of pharmaceutical technology, and more particularly to a method for preparing a side chain intermediate of montelukast sodium, which can achieve the production of Using methanol as a raw material to prepare 1-hydroxymethylcyclopropylacetonitrile greatly simplifies the preparation process steps and is of great significance for industrialization. At the same time, in the synthetic route disclosed in the present invention, the target product has high yield and high purity, does not require complicated post-processing techniques, and is suitable for large-scale industrial production. Finally, the reaction conditions of the present invention are simple and easy to realize, and the synthesis cost is low. |