| abstract |
The invention relates to the technical field of medicinal chemistry, and relates to a TNF-α small molecule inhibitor and a preparation method and application thereof. The present invention identifies the absolute configuration of optical isomer (R)-STU104, especially confirms that STU104 has therapeutic application for autoimmune inflammatory diseases mediated by TNF-α overexpression, including ulcerative colitis, Crohn's disease , rheumatoid arthritis, osteoarthritis, alopecia areata, Sjögren's syndrome, lupus erythematosus and dermatomyositis, etc., has a wide range of clinical significance. |