http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114601801-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114601801-B |
| titleOfInvention | A dual-targeted LDL-MLN nanomedicine and its application |
| abstract | The invention discloses a LDL-MLN nanomedicine with dual-targeting function and its application. The LDL-MLN nanomedicine is obtained by embedding the small molecule inhibitor MLN8237 with LDL particles as a drug carrier. The present invention proves through experiments that LDL-MLN nanomedicine can effectively inhibit the proliferation of HEL cells and MPN primary cells, promote the differentiation and apoptosis of HEL cells and MPN primary cells, reduce the disease burden of PMF mice, and has good safety sex. It shows that LDL is a good drug transport carrier for abnormal megakaryocytes, and the LDL-MLN nanomedicine prepared by the present invention can be used to inhibit tumor cell proliferation and/or promote tumor cell differentiation and apoptosis, and is useful in preventing and/or treating myeloproliferative tumors. , primary myelofibrosis, acute myeloid leukemia has a good application prospect. |
| priorityDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.