| abstract |
Disclosed herein is the use of a polypeptide comprising NIMoEsh for the treatment of a disease or disorder associated with acute myocardial infarction (AMI) in a subject in need thereof, and the use of a polypeptide comprising NIMoEsh in restoring cardiac function following AMI in a subject in need thereof Uses of a polypeptide comprising NIMoEsh to reduce or prevent loss of cardiac function caused by AMI in a subject in need thereof, Use of a polypeptide comprising NIMoEsh to reduce infarction of cardiac tissue caused by AMI in a subject in need thereof, and Use of a polypeptide of NIMoEsh to protect cardiomyocytes from loss of function caused by AMI in a subject in need thereof. Also disclosed herein are methods by which such treatment, restoration, reduction or prevention, reduction and/or protection can be performed, as well as NIMoEsh-containing polypeptides for use in such treatment, restoration, reduction or prevention, reduction and/or protection. |