http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114588111-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4822dfff5709a719ddfb821a88a04d7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate | 2020-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce75b3bf19eb97c6e6becba12707b404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08be9312678fc95740b03934d69a2fd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fd779d1af172c71058f06c74d8ba5c5 |
| publicationDate | 2022-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114588111-A |
| titleOfInvention | A kind of acid-sensitive drug-releasing arsenic trioxide targeted liposome combination and preparation method thereof |
| abstract | The invention belongs to the technical fields of medical technology and nano-medicine, and relates to an acid-sensitive drug-releasing arsenic trioxide targeted liposome combination and a preparation method and application thereof. The arsenic trioxide-loading liposome carrier of the present invention is prepared from phospholipids and cholesterol, and the arsenic trioxide is loaded by the active drug loading method, and has the characteristics of long circulation and acid-sensitive drug release; the surface of the liposome is modified by transferrin, which further has the characteristics of leukemia The characteristics of cell-specific uptake and intracellular lysosome localized drug release can effectively play the role of promoting the apoptosis and differentiation of acute promyelocytic leukemia cells, and inhibiting the function of other myeloid leukemias. Compared with the common arsenous acid injection by slow infusion in the prior art, the arsenic trioxide liposome of the present invention can achieve the curative effect of enhancing efficacy and reducing toxicity through one-time intravenous injection, and can significantly improve the medication compliance of patients. |
| priorityDate | 2020-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.