| abstract |
The present invention relates to immortalized canine stem cells and uses thereof, in particular, to immortalized canine stem cells obtained by transducing and differentiated lentiviral vectors containing E6 and E7 genes of human papilloma virus into canine stem cells and uses thereof. Specifically, the immortalized dog stem cells of the present invention can obtain dog stem cells with the same characteristics and efficacy without repeatedly collecting stem cells by transducing the E6 and E7 genes of human papilloma virus into the dog stem cells. Stem cells and exosome-rich culture medium (ERCM), which is a culture medium of the above-mentioned stem cells, exhibit inhibition of systemic shock reaction caused by allergic reaction, alleviation of itching caused by atopic dermatitis, inhibition of increase in histidine, and improvement of rheumatoid arthritis It has excellent effects such as clinical symptoms of arthritis, and can be effectively used in the treatment of various inflammatory diseases including these diseases. |