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filingDate 2020-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114573689-A
titleOfInvention System and method for continuous purification of biopharmaceutical products
abstract The present invention relates to the field of biopharmaceuticals, and in particular to a system for continuous purification of biopharmaceutical products, comprising (1) at least one main unit of affinity chromatography; (2) at least one main unit of virus inactivation; and (3) At least one main unit for concentration and/or liquid exchange; one or more buffer volumes that are independently and optionally present upstream or downstream of each main unit; wherein each buffer volume is equipped with at least one gravimetric sensor and/or at least one a liquid level sensor, the weight sensor and the liquid level sensor are connected in communication with the management system; the management system controls the purification system to start, continue and stop according to the signal of the weight sensor and/or the liquid level sensor; The concentration and/or exchange unit is a unit for carrying out ultrafiltration or dialysis in continuous operation, in which the flow direction of the stream containing the sample is different from the direction of filtration .
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