| abstract |
The invention belongs to the field of biotechnology medicines. The present invention relates to a polypeptide containing a disulfide bond and having the activity of inhibiting serine protease and its application, and relates to three linear polypeptide molecules having the activity of inhibiting small intestinal protein metabolism enzymes such as trypsin, chymotrypsin (chymotrypsin) and elastase respectively, These polypeptide molecules can be widely fused with other polypeptides or protein drugs with therapeutic activity to form hybrid peptides; hybrid peptides can inhibit the degradation of metabolic enzymes and improve the stability of the polypeptide or protein drugs for the treatment of diseases. The curative effect of drug administration can also promote the direct administration and absorption of polypeptide or protein drugs in the small intestine, and realize the oral administration of protein polypeptide drugs. |