| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e9297c8f247b3724a04ec3c3130f182 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y307-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-48 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-685 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-80 |
| filingDate |
2022-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed217780574e0bf487858c3ed6935724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c98ec1f7403580d752d71329f6cce094
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03a8f1e72ca1914f19f0af3249c73716 |
| publicationDate |
2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114561302-A |
| titleOfInvention |
A kind of high-yielding citric acid Aspergillus niger strain, method and application |
| abstract |
The invention discloses an Aspergillus niger strain (Aspergillus niger) with high citric acid production. The strain is obtained by knocking out the oxaloacetate hydrolase gene oahA in Aspergillus niger, and individually or jointly enhancing the expression of the citric acid transporter encoding genes cexA, Single or co-enhanced expression of glucose low-affinity transporter gene mstC, single or co-enhanced expression of hexokinase gene hxkA, single or co-enhanced expression of phosphofructokinase gene pfkA, single or co-enhanced expression of glucose high-affinity transporter gene mstA, alone or co-enhanced expression Co-enhanced expression of Vibrio vitreous hemoglobin-encoding gene vgb was obtained. The invention eliminates the synthesis of the by-product oxalic acid in the fermentation, thereby improving the conversion rate of the substrate to synthesize citric acid. |
| priorityDate |
2022-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |