http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114560887-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9642ae9da2ac76a2f417623eca08b16 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 2022-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc7c7ec5ecae8df786ad305575af6e8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9097b8bf751436f02e19fa6c87ca593e |
| publicationDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114560887-A |
| titleOfInvention | A kind of preparation method of intermediate for preparing orlistat |
| abstract | The invention relates to the technical field of orlistat preparation, in particular to a preparation method of an intermediate for preparing orlistat. In the preparation process, the Knoevenagel condensation reaction is used to prepare the compound with the structure shown in formula 3, the reaction yield is high, the raw materials are cheap and easy to obtain, the atom economy is high, the introduction cost of the n-hexyl fragment is greatly reduced, and at the same time, it has a relatively low cost. High chiral selectivity (ee value can reach 99.5%); using Noyori asymmetric hydrogenation to introduce two chiral centers in one step with high selectivity, which greatly improves the reaction efficiency and reduces the reaction cost; There are no special requirements for the hydroxyl protecting group in the product, which greatly reduces the production cost and technological difficulty. |
| priorityDate | 2022-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 153.