http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114560821-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_16aa7c804c21a77924ce499924dde57d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10 |
| filingDate | 2022-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a47bbdb65276cfe1dbffd67630fea997 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f64e602e7897b2cb078801b1da0c7d84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e16d5b72db710c4ba1f8241a65484980 |
| publicationDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114560821-A |
| titleOfInvention | A kind of cyclic Gd(III) complex and its preparation method and application |
| abstract | The present invention provides a cyclic Gd(III) complex, which has the chemical structure shown in formula I, and is composed of 1,4,7,10-tetraazacyclododecane-1,4,7,10- The ring structure of tetraacetic acid, namely DOTA, is used as the parent ring, and lipophilic groups are introduced into the α position of phenylacetic acid and the benzene ring structure, respectively. In the formula I, R′ and R″ are introduced, and a chiral group is introduced into the DOTA macrocyclic position. The R in the formula I, the use of the chiral group R to increase the rigidity of the macrocyclic structure improves the stability of the complex, and the lipophilic groups R′ and R″ can combine with the hepatocyte organic anion transport polypeptide, thereby increasing the stability of the complex. When the cyclic Gd(III) complex is used as a contrast agent, the distribution in the liver and gallbladder is improved, that is, the targeting performance is improved. |
| priorityDate | 2022-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.