| abstract |
The invention provides a chitosan-chondroitin sulfate nanoparticle and a drug-carrying joint lubricant, belonging to the technical field of joint lubricants. In the present invention, chitosan has the advantages of good biocompatibility, blood compatibility, biodegradation and human metabolism, etc., can be used as a safe and reliable drug carrier for the treatment of arthritis, and chitosan itself has good bactericidal properties. Chondroitin sulfate contains a large number of hydrophilic sulfonic acid groups, which can endow chitosan nanoparticles with excellent water lubricating properties, so that chitosan-chondroitin sulfate nanoparticles have a good friction reducing effect; chondroitin sulfate itself has cartilage repair properties It can promote the growth of cartilage and lay a good foundation for the drug-loaded treatment and repair function of joint lubricants. Due to the microscopically soft network structure of chitosan nanoparticles, when used as a drug carrier, the drug encapsulated in it can be slowly released at the joint damaged interface, showing an excellent stress-induced sustained release effect. |