| abstract |
The invention discloses a calcitriol sustained-release pellet and a preparation method thereof. The sustained-release pellet is composed of a pill-containing core and a sustained-release coating layer, wherein the pill-containing core contains calcitriol, carboxymethyl Sodium cellulose, filler, binder; sustained-release coating film contains sustained-release matrix material, opacifier, plasticizer, lubricant and purified water. The preparation obtained from the sustained-release pellets obtained by the invention has a good sustained-release effect, can maintain the slow release of the core components within 24 hours, effectively maintain the blood drug concentration of the product, and significantly improve the patient's compliance with the product. |