| abstract |
The problem to be solved by the present invention is to provide a monoclonal antibody against canine CD20 which is superior in effect to conventional antibodies. A monoclonal antibody or antibody fragment directed against canine CD20 is provided, the monoclonal antibody comprising: a heavy chain variable region comprising the amino acid sequence represented by SEQ ID NO: 1, or the amino acid sequence represented by SEQ ID NO: 1 An amino acid sequence in which one or more amino acids are deleted, substituted or added to the amino acid sequence; a light chain variable region comprising the amino acid sequence represented by SEQ ID NO:2, or deleted in the amino acid sequence represented by SEQ ID NO:2, An amino acid sequence with substitution or addition of one to more amino acids; and a light chain constant region comprising the amino acid sequence represented by SEQ ID NO:3, or a deletion, substitution or addition of one to more amino acids in the amino acid sequence represented by SEQ ID NO:3 amino acid sequence of an amino acid. |