http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114539331-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbac48fce2fbe6c39d39351d9cb9cc1e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H23-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2020-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92f37071991a18535fab1463b399984d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_545b071a6096f4bc5a0fb744ca128995 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ec9304eeaab24cbce08caca1af27c90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_972d088fae3b50f54896fe9ecac14da0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11cd875a18b6a53fe7cb226bcae216a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cafc20127c52f5178c898d8a8297a38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_745fa86173011f694eaff9adcadc9bf8 |
| publicationDate | 2022-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114539331-A |
| titleOfInvention | Synthesis and purification method of methylcobalamin |
| abstract | The invention discloses a method for synthesizing, purifying and purifying methylcobalamin, comprising: (1) using vitamin B12 as a raw material, ammonium ferrous sulfate (II) hexahydrate as a reaction solution, and adding sodium borohydride to carry out a reduction reaction; (2) using methyl phosphate as methylating reagent, and using cuprous halide as catalyst to carry out methylation reaction under alkaline conditions; (3) preliminary separation and treatment of reaction product to obtain methylcobalamin crude product; (4) The crude product was purified and purified to obtain pure product. The present invention uses methyl phosphate with low cost, mild reaction conditions, high activity and low toxicity as the methylation reagent, and adopts phosphate-cuprous ion as the catalytic system, so as to realize mild, low toxicity, safety and thorough methylation The reaction greatly improved the quality of the crude methylcobalamin. The refining and purification process of the invention effectively removes impurities introduced in the production process, the maximum single total impurities of the relevant substances are less than 0.1%, and the total impurities are less than 0.2%, which ensures the controllability of product quality. |
| priorityDate | 2020-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.