| abstract |
The present invention discloses a triazine compound having the structure represented by the general formula I or a pharmaceutically acceptable salt, isomer, metabolite, prodrug, solvate or hydrate, pharmaceutical composition and use thereof. The present invention overcomes the defects of single structure of existing anti-coronavirus drugs, lack of non-covalent high-efficiency small molecule inhibitors, etc. The triazine compounds provided by the present invention have good inhibitory activity on 3C-like cysteine protease, It has excellent pharmacokinetic properties and has a good therapeutic effect on infectious diseases. |