| abstract |
The invention provides a continuous hydrogenation reduction method of amide. The method comprises the following steps: under the action of a homogeneous catalyst, the amide and hydrogen are continuously hydrogenated and reduced in a solvent to obtain a hydrogenated reduction product of the amide, wherein the temperature of the continuous hydrogenation and reduction is 100-350° C. ; The structural formula of the hydrogenation reduction product of the amide is ; Wherein, n is any integer from 1 to 5, m is 0 or 1, R 1 , R 2 , R 3 , R 4 are each independently hydrogen, C 1 ～C 18 straight-chain alkyl, C 3 ~C 18 branched alkyl, C 3 ~C 18 cycloalkyl, C 6 ~C 20 aryl, C 6 ~C 20 aralkyl, C 1 ~C 18 alkoxy, silicon oxide R 1 and R 3 , R 2 and R 4 may form a ring respectively, and the ring may be a three-membered ring, a four-membered ring, a five-membered ring, a six-membered ring or a seven-membered ring; the hydrogen on the ring may also be substituted. The method has high yield and can greatly reduce the production cost. |