| abstract |
The invention discloses a preparation method and a product of a sorafenib liver cancer targeting micelle, belonging to the technical field of medicine. The preparation method of the sorafenib liver cancer targeting micelles includes the following steps: (1) dissolving mPEG-NH 2 , adding BLG-NCA and Phe-NCA, adding ether after the reaction is completed, and filtering to obtain mPEG-b -P(LP-co-BLG); (2) dissolving mPEG-b-P(LP-co-BLG) obtained in step (1), adding HBr/acetic acid solution, adding ether after the reaction is completed, filtering, and the precipitate is dialyzed (mPEG-b-P(LP-co-LG)) is obtained later; (3) triethylamine is added after dissolving the mPEG-b-P (LP-co-LG) gained in step (2) with folic acid, and after the reaction is completed , and then mixed with sorafenib solution, stirred, and dialyzed to obtain sorafenib liver cancer targeting micelles. |