| abstract |
The invention relates to a preparation method and application of a macromolecular nitric oxide donor nanomedicine targeting liver parts. Nitric oxide donor-containing polycarbonate block copolymers are obtained from functional polyethylene glycol and nitrate ring carbonate monomers through ring-opening polymerization, and then end groups with amino-containing or modified amino-containing target compounds Modified, the modified copolymer and the small molecule drug are dissolved in an organic solvent, and drug-loaded nanoparticles are obtained by self-assembly. The present invention realizes the synergistic effect of nitric oxide and drug synergistic treatment, and has the advantages of less toxic and side effects, specific targeting, high bioavailability, good drug-carrying capacity, good stability under normal physiological environment, and the like. |