http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114533649-A

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filingDate 2022-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a915b68e59a03b6660eedc1f4a8acee
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publicationDate 2022-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114533649-A
titleOfInvention Separable microneedle array capable of drug delivery and in situ labeling in vivo and preparation method thereof
abstract The invention discloses a drug-deliverable and in-situ-labeled separable microneedle array and a preparation method thereof in the field of microneedle preparation that can be labeled in situ in vivo. Microneedle arrays with thicker tips and thinner bottoms were prepared from methyl cellulose (CMC) and sodium alginate (ALG) aqueous solutions. The separable microneedle array with in-situ labeling function for drug delivery provided by the present invention has effective transdermal drug delivery capability, information labeling storage function and good biocompatibility; by arranging the microneedle array Arbitrary numbers and patterns can be obtained in combination, and intuitive information can be marked on the subject's skin to achieve paperless recording; at the same time, in the application of therapeutic or preventive drug delivery, the human skin is less traumatized, less painful, and less affected. The test subjects have a high acceptance of the microneedle administration method and have a high potential for clinical translation.
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