http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114524803-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d16ab7e36d07c7b3f6a2d5814446d3df |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2022-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f73cc58a54c4d877f2b61eea7c70e5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73b398aff234b3a30582e833187b8094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7833d10abf711aab8fbc38fa865ddc2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e046793b5056d1a1424fd77c0f027376 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dd2585bb2098728312116c7485339e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a6e5ea7568ca893954bad6dd22cf1ed |
| publicationDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114524803-A |
| titleOfInvention | A kind of synthetic method of quinoline compound intermediate |
| abstract | The invention relates to the technical field of organic synthesis, and specifically provides a method for synthesizing a quinoline compound intermediate shown in formula II, comprising the following steps: (1) taking a compound shown in formula IV, a basic catalyst and phenyl chloroformate , contact and react in NMP environment to obtain a reaction solution; (2) mix the reaction solution prepared in step (1) with hydrazine hydrate, react, and obtain, this method can not only realize a two-step homogeneous reaction, but also greatly improves such as The yield of the quinoline compound intermediate shown in formula II, and only the final step purification process is required, and there is no need to replace the new solvent after the original reaction solvent is distilled off in the middle, the operation is convenient, and it is conducive to industrial scale production. The homogeneous reaction also greatly reduces the amount of hydrazine hydrate (the molar equivalent is reduced from 60.0eq in the prior art to 6.0-8.0eq), which is beneficial to environmental protection and production safety. |
| priorityDate | 2022-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.