http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114524705-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a40671744eb3cf08c439b0fdf92f0be9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-35 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C17-35 |
| filingDate | 2022-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e59dac3db2d15674b8b38517f59f9a9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8beabcf9568bb20030807dd2106dde9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57b43388231e3115dd3ff7d2c6132a64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ba17a78162f4c3c9cce25ee336b933f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a16b483f5193314080d91482b95491f5 |
| publicationDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114524705-A |
| titleOfInvention | Synthetic method of 4-bromo-2-fluorobiphenyl |
| abstract | The invention discloses a method for synthesizing 4-bromo-2-fluorobiphenyl, belonging to the technical field of chemical synthesis. The method comprises the following steps: adding dichloromethane and tetrabutylammonium bromide into a bromination reaction kettle, cooling the temperature, and adding dropwise bromine and dichloromethane mixture; add o-fluoroaniline dropwise, after holding for 2 hours, sample and analyze; then filter, add water, benzene, and sodium hydroxide to the filter cake to neutralize, wash the oil layer with water, and azeotropically dehydrate to obtain 2-fluorine -4-Bromoaniline solution; add anhydrous magnesium sulfate, trifluoroacetic acid, cuprous chloride to 2-fluoro-4-bromoaniline solution, cool down, add isopropyl nitrite dropwise, keep warm, filter, rinse Washing, washing, neutralizing, separating, vacuum distillation, rectifying, and finally obtaining a product; the present invention changes the bromination raw material to bromine, and the price of the bromine is far lower than the brominated raw material N-bromosuccinyl in the prior art The imine reduces the synthesis cost and solves the problem of higher cost in the existing 4-bromo-2-fluorobiphenyl synthesis method. |
| priorityDate | 2022-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.