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filingDate 2022-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114517229-A
titleOfInvention Application of serum exosomal RNA in preparation of gestational diabetic macrosomia screening or early diagnosis reagents
abstract The invention discloses the application of serum exosome RNA in the preparation of gestational diabetes macrosomia screening or early diagnosis reagent. The application of reagents for detecting serum exosome-derived mRNA GDF3 and lncRNA AC006064.4 in the preparation of reagents for screening or early diagnosis of pregnant women at high risk of gestational diabetes macrosomia. The present invention utilizes the expression level of serum exosome-derived mRNA GDF3 and lncRNA AC006064.4, combined with maternal age, fasting blood sugar and 2h blood sugar, the specificity for early diagnosis of gestational diabetic macrosomia can reach 1.00, and the sensitivity can reach 0.55. Therefore, the reagents of the above two indicators can be used to assist the early diagnosis of gestational diabetic macrosomia, and provide support for clinicians to accurately predict the risk of macrosomia and take more individualized prevention and treatment plans in a timely manner, thereby minimizing adverse pregnancy outcomes. .
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