| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab6a707674d3df43ed1b013d9fc9912d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate |
2022-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1d1b167ce638832f38fdbf9daa0bfb1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1718014b597e8d9fa429d6b27b03b56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cc367354aa01502f97ed2e730e02cc8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59e6b01be763bf31ac0ebfc56fa66db6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3b4f57970f82a163de32c4ff0649398
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc4c1328e643ae08d82c6dee6af6f0a1 |
| publicationDate |
2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114515272-A |
| titleOfInvention |
A near-infrared responsive gemcitabine prodrug nanopolymer drug and preparation method thereof |
| abstract |
The invention relates to a near-infrared response gemcitabine prodrug nano-polymer medicine and a preparation method thereof. A preparation method of a near-infrared responsive gemcitabine prodrug nano-polymer drug, comprising: (1) conducting a free radical reaction of a thioketal monomer, a coumarin monomer and a methyl polyethylene glycol monomer containing active oxygen responsiveness polymerizing to obtain an amphiphilic polymer; (2) coupling the amphiphilic polymer and gemcitabine to obtain a prodrug polymer; (3) coating the prodrug polymer with a photosensitizer to obtain a The near-infrared response gemcitabine prodrug nanopolymer drug. The invention utilizes the polymerizable functional monomer to realize the one-step preparation of multifunctional polymer prodrug molecules, improves the synthesis efficiency, and makes up for the low utilization rate and strong toxic and side effects of traditional GEM due to easy decomposition by cytidine deaminase in blood circulation. The problem of drug release is solved by using photosensitizer, and the stability of nanocarrier is realized by PEG, and the purpose of biological safety is achieved. |
| priorityDate |
2022-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |