| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2bb875606f3d16c5c4ebddea6fad058 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate |
2022-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07ee73c1c6f1b77b6100c34d4429abac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4675c6c985c61c1df558ffcb6c7473c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ad3ff660a9552a7e21d411d17e7f10e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f8a8bb9b6bc0c024ed50a4b029ff5c9 |
| publicationDate |
2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114507236-A |
| titleOfInvention |
mTOR protein degradation targeting chimera and preparation method and application thereof |
| abstract |
The application belongs to the technical field of medicine, and specifically relates to a mTOR protein degradation targeting chimera and a preparation method and application thereof. The mTOR protein degradation targeting chimeric compound of the present invention exhibits strong mTOR inhibitory ability and inhibits the proliferation of MCF-7. Compound P1 can reduce the expression of mTOR downstream proteins p-S6 (Ser240/244) and p-AKT (Ser473), and further studies showed that our compound inhibited cancer cell growth by inducing autophagy, but not on apoptosis or cell cycle. influences. |
| priorityDate |
2022-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |