| abstract |
The invention discloses a biopolymer material and a preparation method and application thereof. The biopolymer material is prepared by covalent reaction after dissolving a soluble hyaluronic acid polymer material and a reaction additive in water, wherein the soluble hyaluronic acid The mass ratio of the polymer-like material to the mass of the reaction additive is 1:0.005—1:1, and the mixed solution is first subjected to freezing treatment, and then dried to obtain a cross-linked biopolymer material; the soluble hyaluronic acid-based polymer is The material is hyaluronic acid or its organic salt, the molecular weight of the soluble hyaluronic acid polymer material is 50,000-1,300,000 Daltons, and the reaction additive is a multi-arm structure reaction additive. The physical and chemical properties of the new biopolymer material prepared by the invention are changed, which greatly increases its degradation half-life or dissolution time, and can be used in the field of medicine, especially in biological dressings, absorbable biological materials and drug buffers. controlled release use. |