http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114478797-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2133ad971d9dde1722c8bbd9bd9c3dbd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0ba724ef1d1f3c1e9e86d2ddf50d572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5eb2941d91322fafbcc1101addaab52e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85bd0ccb8fa91ffd0cc574bbb454f9ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20598a2f0b3df406e1cfc94d781ac11c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb34e797df0396ca9b297d6ea8aea57c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b4061d3edb67012e3341b8f119d6784 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_349eb6d452fbb238b78a9b20db60c5de |
| publicationDate | 2022-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114478797-A |
| titleOfInvention | A hydrolysis targeting chimera targeting DDX24 protein and its application |
| abstract | The present invention discloses a series of PROTAC polypeptides with amino acid general formula (1) targeting DDX24 protein degradation, the specific sequence of which is: (1) R1-Ahx linker-E3 ligand-R2. Among them, R1 is a polypeptide that targets and binds to DDX24 protein, including TVCTWYCYCAAYQRA or LT(p)FEHYWAQLTS(p), and the linker is a branched or unbranched, cyclic or acyclic chain containing 6 carbon atoms represented by Ahx , the amino acid linking part of the saturated or unsaturated chain, the E3 ligand is the ligand of the ubiquitin ligase VHL (ALAPYIP). R2 is a cell penetrating peptide, including R D RR D RR D RRR or RRRRRRRR (RD refers to D -configuration arginine, R refers to L-configuration arginine). The present specification generally relates to compounds of general formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2 are any of the meanings defined herein. The present specification also relates to the use of such chimeras and pharmaceutically acceptable salts thereof in the treatment of tumors in human or animal bodies. The specification also relates to methods and intermediate compounds involved in the preparation of such chimeras, and to pharmaceutical compositions containing such compounds. |
| priorityDate | 2021-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.