| abstract |
The invention discloses a pharmaceutical co-crystal of estriol and a preparation method and application thereof. The drug co-crystal of estriol is formed by the active ingredient estriol and the co-crystal former urea, and the estriol and the urea are connected by hydrogen bonds. The estriol-urea co-crystal prepared by the invention has good stability, significantly improved solubility, and significantly increased bioavailability, and the co-crystal can control the release of estriol, prolong the delivery of estriol, and has the advantages of reducing dosage and related side effects. potential. The co-crystal reagent used in the present invention is cheap, and the co-crystal preparation adopts methods such as ball milling with low production cost, so the co-crystal method is used to improve the water solubility of the drug without significantly increasing the drug production cost, and the basic price of the co-crystal drug can be guaranteed. Stablize. |