http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114478452-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf1b62cce4a4e8372fde38998774a4b3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-88 |
| filingDate | 2022-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57386e9436531190643355d5bf00dfcc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18f9330b583289b4bf8ccceb050deb7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1696612ecf10b799fdd092608b783ec7 |
| publicationDate | 2022-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114478452-A |
| titleOfInvention | A kind of preparation method of mycophenolate sodium |
| abstract | The invention belongs to the field of medicine, and in particular relates to a preparation method of mycophenolate sodium. The invention uses mycophenolic acid as a raw material to prepare an M2 crystal form mycophenolic sodium crude drug suitable for preparation. The preparation method of sodium mycophenolate provided by the invention uses mycophenolic acid of various purities as raw materials, can be purchased commercially, and the source of raw materials is easy to obtain; a solvent of methyl isobutyl ketone with low toxicity is used, which is easy to recover, The production cost is low, and at the same time, methyl isobutyl ketone is used as a crystallization solvent, and the crystallization conditions are mild, the obtained mycophenolate sodium is in the M2 crystal form, and the bulk density is in the range of 0.3-0.5 g/mL, which is convenient for the use of pharmaceutical preparations. The preparation method of mycophenolate sodium provided by the invention has a crystallization yield of over 93%, and the process is simple and convenient for industrial production. |
| priorityDate | 2022-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.