| abstract |
The invention discloses an axial chiral sulfur-containing biaryl derivative and a synthesis method thereof, belonging to the technical field of organic chemical synthesis. The structural formula of the axial chiral sulfur-containing biaryl derivative is formula (I), and the synthesis method thereof For: reacting the biaryl phenol shown in the formula (II) with the thioaryl reagent shown in the formula (III) in the presence of a 3,3'-disubstituted binaphthyl derivative selenide catalyst shown in the formula (IV) , to obtain the axial chiral sulfur-containing biaryl derivative represented by formula (I). The axial chiral sulfur-containing biaryl derivative represented by the formula (I) of the present invention has a high enantiomeric excess (ee) value, and the synthesis method thereof has mild reaction conditions, good repeatability, cheap and easy-to-prepare raw materials, and basically no It has a wide range of toxicity and substrate application and is economical. |