| abstract |
The invention belongs to the interdisciplinary technical fields of chemistry, pharmacy, medicine and the like, and more particularly, relates to a nano-drug-carrying system of folic acid-hydroxyalkyl starch macromolecules stably co-carrying photosensitizers and small molecule prodrugs, and preparation and application thereof . The nano-drug loading system includes a photosensitizer and self-assembled nanoparticles of a reduction-responsive hydrophobic small molecule prodrug, and also includes a folic acid-hydroxyalkyl starch macromolecular compound. Experiments show that the folic acid-hydroxyalkyl starch macromolecular compound The introduction of the drug can significantly improve the stability of self-assembled nanoparticles of photosensitizers and hydrophobic small-molecule prodrugs. It is targeted and realizes photoacoustic and fluorescence imaging of the tumor site. At the same time, laser irradiation can rapidly heat up the tumor site, and the chemotherapeutic effect of doxorubicin can be improved by hyperthermia to achieve synergistic treatment. |