| abstract |
The invention discloses a recombinant human CHK1 protein kinase hydrogel for promoting myocardial regeneration, a preparation method and application thereof, and belongs to the technical field of biomedicine. Recombinant human CHK1 protein kinase includes CHK1 protein kinase sequence and penetrating peptide sequence. After injection, it can affect the DNA synthesis, cell cycle, mitosis and other processes of cardiomyocytes by activating the key pathways of myocardial regeneration, and promote myocardial regeneration after acute myocardial infarction. Repair, reduce myocardial infarction size and fibrosis, and improve recovery of cardiac function. At the same time, the three-dimensional network structure formed by the liquid coagulation of the small molecule hydrogel can provide mechanical support for the ventricle and delay ventricular remodeling; the porous structure of the small molecule hydrogel facilitates the growth of regenerated cardiomyocytes and promotes myocardial repair. |