| abstract |
The present invention relates to a nucleic acid molecule encoding an interleukin-1 receptor antagonist protein, a transgene expression cassette comprising the nucleic acid molecule, a gene delivery system comprising the transgene expression cassette and applications thereof. The transgene expression cassette and gene delivery system of the present invention can be used to treat various diseases that can be improved by blocking IL-1 signaling pathway, including malignant tumors and inflammatory diseases, such as joint inflammation, especially osteoarthritis. |