http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114456125-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-36 |
| filingDate | 2022-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114456125-B |
| titleOfInvention | A kind of preparation method of small particle size epalrestat crystal |
| abstract | The present application provides a method for preparing small-sized epalrestat crystals. The small particle size epalrestat described in this application is crystal form B, and the small particle size means that the main particle size D50 is 3-6 μm. The preparation method comprises: adding the crude product of epalrestat into an alcoholic solvent to dissolve, filtering and collecting the filtrate and stirring; adding an alkane solvent to the above filtrate and stirring, then performing crystallization; filtering and washing the filter cake with an organic solvent, and drying, namely Obtain small particle size epalrestat crystalline product; Wherein, described alcoholic solvent is methyl alcohol, ethanol, isopropanol or n-butanol; Described alkane solvent is normal heptane, normal hexane or hexanaphthene; The described washing The organic solvent is methanol, ethanol, isopropanol or n-butanol; the temperature in the preparation process is controlled at not higher than 80°C. The method can obtain the epalrestat product with good powder fluidity and controllable particle size distribution without crushing, has high yield and high purity, is simple, easy to implement, low in cost, and easy to industrialized production. |
| priorityDate | 2022-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.