http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114456092-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_289b27060c4068b6527059ac84bd9413 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_acaa96e71ca48522b1b8c8ffe50e1007 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C273-189 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C273-18 |
| filingDate | 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c6100ca82e9593efb3a57cf86e0ffce |
| publicationDate | 2022-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114456092-A |
| titleOfInvention | A kind of method for separating and purifying Cinacalcet intermediate impurities |
| abstract | The invention discloses a method for separating and purifying intermediate impurities of cinacalcet. The first step of sample solution of impurity of Kasai intermediate; liquid analytical chromatograph was used to analyze the purity of the sample solution and the existence of other impurities; the nano-unisil reverse silica gel chromatography packing was used as the stationary phase, and 0.1% TFA was used as the mobile phase A, 100% acetonitrile was used as mobile phase B, and the second HPLC purification was performed to remove impurities with similar physical and chemical properties; the solvent was removed to obtain a sample solution of cinacalcet intermediate impurities, which was lyophilized by a freeze dryer to obtain impurities. After two HPLC purifications, the purity of the sample obtained in the first time is 71.35%, and the purity of the sample obtained in the second time is 99.41%, which improves the purity and yield of the impurities of the cinacalcet intermediate. |
| priorityDate | 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.