| abstract |
The invention discloses an ionizable lipid and a preparation method and application thereof. The structural formula of the ionizable lipid is as follows: The ionizable lipids of the present invention are positively charged under acidic conditions, and can electrostatically attract the negatively charged phosphate groups of mRNA, the halogen-containing alkyl groups can have better affinity with the membrane, and at the same time, they have a hydroxyl structure It is easy to form hydrogen bonds with the bases of mRNA, so as to achieve good coupling effect and high encapsulation efficiency. |