| abstract |
The invention relates to the technical field of medicine, and discloses a maleate salt of a nicotinyl alcohol ether derivative as well as its crystal form and application, namely (S)-N-(2-(pyridine-3-methoxy)-4-( 2-Bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate and its stereoisomers, crystal forms and preparation methods, pharmaceutical compositions and uses thereof. Specifically, relate to S)-N-(2-(pyridine-3-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) shown in formula I Serine isopropyl ester maleate and its crystalline form, its stereoisomer and its preparation method, the composition containing this compound or its crystalline form, and this compound or its crystalline form in the preparation of treatment and PD-1/PD Use in medicines for diseases related to L1 signaling pathway, such as cancer, infectious diseases, and autoimmune diseases. |